Benign Prostatic Hyperplasia
Dosage and administrations:
Benign Prostatic Hyperplasia:
Adults: 0.4mg once daily, 30 min after the same meal each day
Titrate: May increase to 0.8mg once daily after 2-4 weeks if response is inadequate
If therapy is discontinued or interrupted for several days at either the 0.4mg or 0.8mg dose, restart with 0.4mg once daily.
Do not crush, chew, or open cap
Pregnancy and breastfeeding:
Category B, not for use in nursing.
Warning and precautions:
Orthostasis/syncope may occur; caution to avoid situations in which injury could result.
May cause priapism.
Prostate cancer and BPH frequently coexist.
Intraoperative floppy iris syndrome (IFIS) observed during cataract and glaucoma surgery; initiation of therapy in patients who are scheduled for cataract or glaucoma surgery is not recommended.
Allergic reaction reported (rare) in patients with sulfa allergy.
Headache, dizziness, rhinitis, infection, abnormal ejaculation, asthenia, back pain, diarrhea, pharyngitis, chest pain, cough increased, somnolence, insomnia, sinusitis, nausea.
Avoid with other α-adrenergic blockers.
Caution with cimetidine, particularly at a dose >0.4mg, and warfarin.
Avoid with strong inhibitors of CYP3A4 (eg, ketoconazole).
Caution with moderate inhibitors of CYP3A4 (eg, erythromycin), with strong (eg, paroxetine) or moderate (eg, terbinafine) inhibitors of CYP2D6, and in patients known to be CYP2D6 poor metabolizers, particularly at a dose >0.4mg.
Caution with PDE-5 inhibitors; may cause symptomatic hypotension.
Store below 30°C.
Protect from extreme heat and moisture.
Keep out of reach of children.