Oxyvet® 20% LA
Oxytetracycline long acting
Each ml contains 200 mg oxytetracycline base
Tetracyclines generally act as bacteriostatic antibiotics and inhibit protein synthesis by binding to 30S ribosomal subunits of susceptible organisms, thereby preventing binding to those ribosomes of aminoacyl transfer-RNA. Tetracyclines also are believed to reversibly bind to 50S ribosomal subunits and additionally alter cytoplasmic membrane permeability in susceptible organisms. In high concentrations, tetracyclines can also inhibit protein synthesis by mammalian cells.
After IM administration of long acting oxytetracycline, absorption occurs slowly. Tetracyclines as a class, are widely distributed in the body, including to heart, kidney, lungs, muscle, pleural fluid, bronchial secretion, sputum, bile, saliva, urine, synovial fluid, ascetic fluid, and aqueous and vitreous humor. Only small quantities of oxytetracycline are distributed to the CSF and therapeutic levels may not be attainable. Tetracyclines cross the placenta, enter fetal circulation and are distributed into the milk. Oxytetracycline is eliminated unchanged primarily via glomerular filtration.
Oxyvet LA is indicated in acute and chronic respiratory diseases, septicemia, metritis, black leg, anaplasmosis, enzootic abortion in ewes and other susceptible infections.
Oxytetracycline has activity against most mycoplasma, spirochetes (including the Lyme disease organism), Chlamydia and Rickettsia. Also it has activity against some strains of staphylococci and streptococci. Gram positive bacteria that usually covered by tetracycline, include Actinomyces sp., Bacillus anthracis, Clostridium perfringes and tetani, Listeria monocytogenes and Nocardia.
Cattle, calf, Goat and Sheep
Administration and Dosage:
Recommended dose is 5-10 mg/kg b.w.
20 mg / kg BW, deep IM in severe cases repeat administration with same dose 3-5 days later
IV injection does not show long acting effects and could be administered 10 mg/kg
Contraindications and Warnings:
Oxytetracycline is contraindicated in patients hypersensitive to it or other tetracyclines. Because tetracyclines can retard fetal skeletal development and discolor deciduous teeth, they should only be used in the last half of pregnancy when the benefits outweigh the fetal risks. In patients with renal insufficiency or hepatic impairment, it must be used cautiously. Administer IV rout slowly. Do not inject more than 10 ml in one site.
Oxytetracycline given to young animals can cause discoloration of bones and teeth to a yellow, brown or gray color. When administered IM local reactions, yellow staining and necrosis may be seen at the injection site. In small animals it can cause nausea, vomiting, anorexia and diarrhea.
Meat: 21 days
Milk: 7 days
Store in a cool place (5°C-15°C) and protect from direct sunlight and freezing.
Keep out of reach and sight of children.
50 and 100 ml ember glass vials
Product License Number from IVO: 80-126-A.B
For Veterinary Use Only