Keptofen
Keptofen
Keptofen® 10 %
Ketoprofen
Injectable solution
Pharmaceutical Category:
NSAID
Composition:
Each ml contains 100 mg ketoprofen
Pharmacology:
Ketoprofen exhibits actions similar to that of other NSAIDs in that it possesses antipyretic, analgesic and anti-inflammatory activity. It’s mechanism of action is the inhibition of cyclooxygenase catalysis of arachidonic acid to prostaglandin precursors (endoproxides), thereby inhibiting the synthesis of prostaglandins in tissues. Ketoprofen purportedly has inhibitory activity on lipoxygenase, whereas flunixin reportedly does not at therapeutic doses.
Pharmacokinetics:
Ketoprofen is rapidly absorbed after IM administration. It’s highly distributed throw different body tissues; in horse up to 93% of the drug bound to the plasma albumins (in horses). ketoprofen enter synovial fluid and reach high levels. The onset of activity is within 2 hours and peak effects 12 hours post dose.
Ketoprofen is eliminated via the kidneys as a conjugated metabolite (glocogenic Ester) and unchanged drug. The elimination half life in horses is approximately 1.5 hours.
Target animals:
Cattle, Horses, Dogs and Cats
Administration of ketoprofen up to 5x over labeled dosage in horse dose not exhibit any sign of toxicity.
Indications:
Ketoprofen used as an antipyretic, anti inflammatory and analgesic especially in musculoskeletal disorders.
Horses: Treatment of Synovitis , Artiritis, Tenosynovitis, Osteocondrytis, Laminitis, Colic and soft tissue inflammation after surgery.
Cattle: treatment of mastitis and pneumonia in addition with antibiotic therapy.
Dosage:
Horse: 2.2 mg/kg BW, IM or IV injection, once daily, up to 5 days.
Cattle: 3 mg/kg BW, IM or IV injection, once daily, up to 3 days.
The following doses are mentioned in Veterinary drug handbook 4th edition 2002 for these animals:
Dogs: 1 – 2 mg/kg BW, IM, IV or SC injection
Cats: 1 – 2 mg/kg BW, SC injection
Rabbits: 1 mg/kg BW, IM injection q12-24h
Birds: 2 mg/kg BW, IM injection q8-24 hours
Withdrawal time:
Meat: 28 days
Milk: 7 days
Contraindications and Warning:
Do not use in horse during race.
Do not inject in joint.
Do not use if sedimentation occurs.
In cases of GI ulceration, renal or hepatic impairment and late pregnancy using this drug is not recommended.
Storage:
Store at room temperature (below 30°C).
Protect from freezing and direct sunlight.
Keep out of reach and sight of children
Presentation:
50 and 100 ml amber glass vials
Product License Number from IVO: 88-127-S
For Veterinary Use Only
