Solution for injection
Each ml contains 50 mg Enrofloxacin
Enrofloxacin as a fluoroquinolone antibiotic has bactericidal activity. This activity is concentration dependent, with susceptible bacteria cell death occurring within 20-30 minutes of exposure. Enrofloxacin has demonstrated a significant post-antibiotic effect for both gram – and gram + bacteria and is active in both stationary and growth phases of bacterial replication. Its mechanism of action is inhibiting bacterial DNA-gyrase (a type-II topoisomerase), thereby preventing DNA supercoiling and DNA synthesis. This agent has good activity against many gram negative bacilli and cocci, including most species and strains of Pseudomonas aeruginosa, Klebsiella spp., E.coli, Enterobacter, Campylobacter, Shigella, Salmonella, Aeromonas, Haemophilus, Proteus, Yersinia, Serratia, and Vibrio species. Other organisms that are generally susceptible include Brucella sp, Chlamidia tracomatis, Staphyloccoi (including penicillinase-producing and methicillin-resistant strains), Mycoplasma, and Mycobacterium sp. (not the etiologic agent for Johne’s Disease). This drug has weak activity against most anaerobes and is ineffective in treating anaerobic infections.
Enrofloxacin is distributed throughout the body. Highest concentrations are found in the bile, kidney, liver, lungs and reproductive system. Enrofloxacin reportedly concentrate in macrophages. Therapeutic levels are also attained in bone, synovial fluid, skin, muscle, aqueous humor and pleural fluid. Low concentrations are found in the CSF, and levels may only reach 6-10% of those found in the serum. Enrofloxacin is eliminated via both renal and non-renal mechanisms. Approximately 15-50% of the drugs are eliminated unchanged into the urine, by both tubular secretion and glomerular filtration. Because of the dual means of elimination, patients with severely impaired renal function may have slightly prolonged half-lives and higher serum levels which may not require dosage adjustment.
Cattle, Calves, Sheep and Goats
Enrofloxacin is indicated in treatment of Dermal, Gastrointestinal, Urogenital, Respiratory and soft tissue infections.
Cattle and Sheep: For treatment of GI infections (salmonellosis, colibacillosis and pasteurellosis), pulmonary tract infections (bronchopneumonia, pleuropneumonia and mycoplasma infections).
Dog and Cat: For treatment of otitis & osteomyelitis.
Administration and Dosage:
Cattle: 2.5 mg/kg b.w (0.5 ml per 10 kg b.w), SC for 3-5 consecutive days.
Dog & Cat: 2.5-5 mg/kg b.w SC injection for 3-5 consecutive days.
Sheep & Goat: 2.5 mg/kg b.w (0.5 ml per 10 kg b.w), SC or IM for 3-5 consecutive days.
Note: Dose may be increased to 1 ml per 10 kg b.w in acute infections.
Contraindications and Warnings:
Do not use in horse. Do not inject in mammary tissue. Do not use Enrofloxacin in young growing animals due to potential cartilage abnormalities. Hypersensitivity reactions could potentially occur. Animals should not be allowed to become dehydrated during therapy. Enrofloxacin is not generally recommended to be used during pregnancy unless the benefits of therapy clearly outweigh the risks.
Meat: 28 days
Milk: 7 days
Keep in room temperature (25°C). Protect from direct sun light.
Keep out of reach and sight of children.
50 ml amber glass vials
Product Licence Number from IVO: 75-31-A.B
For Veterinary Use Only