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Tyloject 20%


Solution for Injection

Pharmaceutical Category:



Each ml contains 200 mg Tylosin base


Tylosin is a macrolide antibiotic related structurally to erythromycin. It is usually a bacteriostatic agent but in high concentrations or against highly susceptible organisms it may be bactericidal. Macrolides are believed to act by binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting peptide bond formation. This drug has in vitro activity against gram positive cocci (staphylococci, streptococci), gram positive bacilli (Bacillus anthracis, Corynebacterium, Clostridium spp. (not C.difficile), Listeria, Erysipelothrix), some strains of gram negative bacilli, including Haemophilus, Pasturella, and Brucella. Some strains of Actinomyces, Mycoplasma, Chlamidia, Ureaplasma, and Ricketsia are also inhibited by tylosin. Most strains of the family Enterobacteriaceae (Pseudomonas, E.coli, Klebsiella, etc.) are resistant to tylosin.


Tylosin base injected SC or IM is reportedly rapidly absorbed. Tylosin is well distributed in the body after systemic absorption, with the exception of penetration in to the CSF. Tylosin is eliminated in the urine and bile apparently as unchanged drug. The elimination half-life of the tylosin is reportedly 54 minutes in small animals, 139 minutes in newborn calves and 64 minutes in calves 2 months of age or older. 

Target animals:

Cattle, Sheep, Goats, Dogs and Cats


Tylosin is indicated in treatment of most gram-positive and certain gram-negative (not including coli forms) which includes: Streptococcus, staphylococcus, corynebacterium, clostridium, Erysipelothrix, vibrio, spirochetes, Mycoplasma (PPLO), pasteurella and Chlamydia.

Cattle: Pneumonia, pneumoenteritis, calf diphtheria, contagious pleuropneumonia, arthritis, foot rot, uterus infections, mastitis.

Sheep: Acute agalactia, pneumonia, mastitis.

Goat: Contagious pleuropneumonia.

Dog & Cat: upper and lower pulmonary tract infection, otitis and post surgery infections.

Administration and Dosage:

Cattle, Sheep and Goat: 10 mg/ kg b.w. IM, for 5consecutive days

Dog & cat: 2-10 mg/ kg b.w.

The following doses are mentioned in Veterinary drug handbook 4th edition 2002 for these animals:

Rodents (Rabbits, Hamsters, Gerbils and Rats): 10 mg/kg BW, SC, q24h

Birds: 10-40 mg/kg BW, IM, q12h

Reptiles: 5 mg/kg BW, IM, q24h

Contraindications and Warning:

Do not administer in horse, administration may lead to death. Tylosin is contraindicated in patients hypersensitive to macrolides. It is unlikely to have serious teratogenic potential. Drug interactions with tylosin have not been recorded.

Side effects:

Most likely adverse effect with tylosin are pain and local reactions at intramuscular injection sites, and mild GI upset.


Tylosin is relatively safe in most overdose situation and do not produce toxicity up to 100X of therapeutic dose.

Withdrawal Time:

Milk: 72 hours for cattle and 48 hours for ewes

Meat: 7 days for cattle and sheep


Store below 30°C. Protect from direct sunlight and freezing.

Keep out of reach and sight of children


50 ml and 100 ml transparent glass vials


The normal color spectrum of this solution may differ from light to dark yellow


Product License Number from IVO: 72-35-A.B


For Veterinary Use Only

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