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Products > Human Product > Supplements > Zinc-sulphate

Zinc-sulphate


Composition:

Each 5ml contains 22mg Zinc sulfate 7H20 equivalent to 5 mg zinc. (1)

Category:

Mineral supplements.

Pharmacology:

Act as integral part of several enzymes important to protein and carbohydrate metabolism, wound healing, maintenance of normal growth and skin hydration, and senses of taste and smell. (4)

Pharmacokinetics:

Absorption: Some studies indicate that ingestion with certain foods may inhibit Zinc absorption.
It is poorly absorbed from the GI tract (Only 20% to 30%). (5)
Distribution: Major stores of zinc are in the skeletal muscle and bone. (5)
Elimination: About 90% is excreted through the intestine; about 2% in the Urine. (5)

Indications:

Zinc is an essential mineral for human cell growth, differentiation, and DNA synthesis. Zinc plays a critical role in the development and maintenance of a healthy immune system. There are many associations with diarrhea and increased fecal zinc loss, negative zinc balance, and low tissue zinc concentrations. High zinc loss during diarrhea has been observed in infants.
Zinc Sulfate Syrup 5 mg/5 ml
RAZAK LABORATORIES
Km. 10, Karaj Makhsus Rd., Tehran 13185, Iran
Zinc supplementation for the treatment of diarrhea may also be critical in improving overall immune function.

Unlabled use of Zinc sulfate:

Treatment of acrodermatitis enteropathica and delayed wound healing associated with zinc deficiency, treatment of acne, rheumatoid arthritis, Wilson's disease. (1, 2, 3)

Warnings:

This Product should not be used by pregnant or lactating women. (1, 2)

Precautions:

Pregnancy: Category C, Routine supplementation during pregnancy is not recommended. Lactation: Excreted in breast milk.
Renal function: Dosage reduction may be required in patients with renal dysfunction.
Excessive intake: In healthy people may be harmful. (4)

Drug interactions:

Fluoroquinolones, Tetracyclines, Copper, Metal lons, Penicillamine: Absorption of these agents may be decreased. (1, 4, 5, 6)

Adverse reactions:

Nausea, Vomiting (especially in large oral doses), Abdominal pain, somnolence, Malaise, nervousness, hypertonia, pain, dizziness, insomnia. (1, 4, 5)

Overdose:

Nausea, Vomiting, dehydration, restlessness, sideroblastic anemia, profuse sweating, hyperamylasemia are may be the overdose symptoms of zinc sulfate, contact a poison control center. (1, 4, 5)

Before using this medication:

Tell patient to take with food if GI upset occurs but to avoid foods high in calcium, phosphorus and phytate. Inform patient that bran, caffeine, and dairy products may decrease absorption. Tell patient to contact health care provider if nausea, severe vomiting dehydration, or restlessness occurs. (5)

Administration and dosage:

Zinc is usually given by mouth in doses of up to 50 mg of elemental zinc three times daily. Oral zinc salts, may be used as copper absorption inhibitors in Wilson's disease. The usual adult dose is 50 mg three times daily upto a maximum of five times daily.
Children: 5-8 ml daily
Adults: 25 ml daily (Up to 40 ml)
Nursing mothers: 22.5 ml

Packaging and storage:

Store at room temperature between 20 to 25C. (5)

How supplied:

Zinc sulfate is available as 120 ml syrup with 5mg/5ml.

References:

1- Martindale 35
2-PDR 2007
3-WHo model list of essential medicine
4-www.drugs.com
5-www.American chronicle.com
6-USP DI 2005
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