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prazosin Tablets 1& 5 mg



Alpha1-blocker (quinazoline)



Each tablet contains: prazosin (as hydrochloride)    1 or 5 mg



Treatment of :


Congestive heart failure : Prazosin may be used as an adjunct to digoxin and diuretics for the treatment of congestive heart failure. However, prazosin has not been shown to improve survival in these patients.

Toxicity , ergot alkaloid: prazosin is used for treatment of peripheral vasospasm caused by ergot alkaloid overdose.

Pheochromocytoma : prazosin is used for the management of hypertension associated with pheochromocytoma.

Reynaud’s phenomenon

Benign prostatic hyperplasia (BPH) : prazosin is used for the treatment of urinary symptoms associated with benign prostatic hyperplasia. Prazosin has been shown to improve urinary flow and symptoms of BPH. However, the long – term effects of prazosin on the incidence of acute urinary obstruction or other complications of BPH or on the need for surgery have not yet been determined .



Hypersensitivity to any of the product’s ingredients.


Precaution & warnings:

May cause marked lowering of BP especially postural hypotension and syncope with the 1st dose or 1st few days of therapy; similar effect may be anticipated if therapy is discontinued for several days and then restarted. minimize syncopal episodes by limiting initial dose to 1mg, by subsequently increasing the dose slowly, and by introducing any additional antihypertensive with caution.

May impair physical/mental abilities.

Examine patients with BPH to rule out prostate cancer prior to initiation of therapy.

Priapism (rare) reported. Monitor for signs/symptoms of priapism.

Intraoperative floppy iris syndrome observed during cataract surgery.


Safety and efficacy have not been established for pediatrics.          



Pregnancy & Breastfeeding:

Category C, caution in nursing.


Dosage and administration:



“ If discontinued for several days or longer, restart using the initial dosing regimen. “

Treatment of hypertention:

Initial Dose:

1 mg two or three times a day

Maintenance Dose :

Dosage may be slowly increased to a total daily dose of 20 mg given in divided doses. The therapeutic dosages most commonly employed have ranged from 6 mg to 15 mg daily given in divided doses. Doses higher than 20 mg usually do not increase efficacy, however a few patients may benefit from further increases up to a daily dose of 40 mg given in divided doses. After initial titration some patients can be maintained adequately on a twice daily dosage regimen.

Use With Other Drugs :

When adding a diuretic or other antihypertensive agent, the dose should be reduced to 1 mg or 2 mg three times a day and retitration then carried out.

Toxicity , ergot alkaloid : oral , 1 mg three times a day .

Vasospastic therapy adjunct – Reynaud’s phenomenon : oral , 1 mg three times a day.

 Benign prostatic hyperplasia :

Initial : oral , 1 mg ( base ) two times a day .

Maintenance : Oral , 1 to 5 mg ( base ) two times a day.

Usual adult prescribing limits : Daily doses higher than 20mg ( base ) usually do not have increased efficacy, although some patients respond to up to 40mg a day.



Side effects:

Dizziness, headache, drowsiness, lack of energy, weakness, palpitations, nausea/vomiting, edema, orthostatic hypotension, dyspnea, syncope, depression, urinary frequency, diarrhea.


Drug interaction:

Additive hypotensive effects with diuretics, β-blockers (eg, propranolol), or other antihypertensives. Additive BP-lowering effects and symptomatic hypotension with PDE-5 inhibitors.



Store below 30°C. Protect from light.

Keep out of reach of children.

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