Antihypertensive : congestive heart failure vasodilator ; antidote ( to ergot alkaloid poisoning ) ; vasospastic therapy adjunct; benign prostatic hyperplasia therapy agent. ( USP DI 2001 )
Each tablet contains prazosin hydrochloride equivalent to 1or 2 or 5 mg of prazosin.
Prazosin hydrochloride ,a quinazoline derivative , is the hydrochloride salt of 1 – ( 4 amino – 6,7 – dimethoxy- 2 – quinazolinyl ) – 4(2-furoyl) piperazine and its structural
formula is :
Mechanism of Action :
Prazosin is a selective alpha 1 - adrenergic blocking agent . The alpha 1 - adrenergic blocking action is thougth to account primarily for its effects.
Prazosin produces vasodilation and reduces peripheral resistance but generally has little effect on cardiac output .Antihypertensive effect is usually not accompanied by reflex tachycardia. There is little or no effect on renal blood flow or glomerular filtration rate.
Usage in pregnancy :
Drug Interactions :
Dosage and Administration :
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