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Products > Human Product > Antibiotics > Tetracycline

Tetracycline Capsule 250 mg


Tetracycline antibiotic


Each capsule contains:

Tetracycline hydrochloride    250 mg



Oral tetracycline is indicated for treatment of Brucellosis, Syphilis, Gonorrhea, Acne, peptic ulcer desease and Chlamydia trachomatis Infections.



§  The tetracyclines are contraindicated in patients hypersensitive to any of this group of antibacterials.

§  May cause permanent teeth discoloration during tooth development (last half of pregnancy, infancy and childhood to 8 yrs of age); avoid use in this age group unless other drugs are not likely to be effective or are contraindicated.


Precaution & warnings:

§  May lead to excessive systemic accumulation and possible liver toxicity if renal impairment exists; lower than usual doses are indicated and if therapy is prolonged, determine serum levels.

§  Photosensitivity reported; discontinue at first evidence of skin erythema.

§  Care should be taken if tetracyclines are given to patients with hepatic impairment and high doses should be avoided.

§  Serum monitoring may be helpful in patients with risk factors given prolonged therapy. It has been suggested that serum concentration of tetracycline should not exceed 15 mcg/mL.

§  To avoid the risk of oesophageal ulceration, take with plenty of fluid while sitting or standing, and well before going to bed.


Pregnancy & Breastfeeding:

Category D, not for use in nursing.

Dosage and administration:

General Dosing

500mg bid or 250mg qid; may require higher doses (eg, 500mg qid) for severe infections or for those infections not responsive to smaller doses
Continue for at least 24-48 hrs after symptoms and fever subside

Side effects:

Anorexia, nausea, vomiting, epigastric distress, diarrhea, maculopapular/erythematous rashes, urticaria, angioneurotic edema, hemolytic anemia, thrombocytopenia, nail discoloration.


Drug interaction:

§  May interfere with bactericidal action of penicillin; do not coadminister.

§  May depress plasma prothrombin activity; may require downward adjustment of anticoagulant dose.

§  Fatal renal toxicity reported with concurrent methoxyflurane.

§  Antacids containing aluminum, Ca2+, or Mg2+, and preparations containing iron, zinc, or sodium bicarbonate may impair absorption.

§  Food and dairy products may interfere with absorption. May render oral contraceptives less effective.




§  Store below 30°C.

§  Protect from light and moisture

§  Do not use after expiration date.


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