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Doxycycline capsules 100 mg






Each capsule contains:

Doxycyline monohydrate            100 mg



§  Gonococcal Infections

§  Acute Epididymo-Orchitis

§  Syphilis

§  Chlamydia trachomatis Infections

§  Nongonococcal Urethritis

§  Inhalational Anthrax (Postexposure).

§  Treatment of the Following Infections Caused by Susceptible Microorganisms:
Rocky Mountain spotted fever
Typhus fever and the typhus group
Q fever
Tick fevers
Respiratory tract infections
Lymphogranuloma venereum
Psittacosis (ornithosis)
Inclusion conjunctivitis
Relapsing fever
Campylobacter fetus infections
Brucellosis (in conjunction w/ streptomycin)
Granuloma inguinale

§  Treatment of Infections Caused by the Following Susceptible Strains:
Escherichia coli
Enterobacter aerogenes
Shigella species
Acinetobacter species

§  Treatment of the Following Infections Caused by Susceptible Microorganisms When Penicillin is Contraindicated:
Uncomplicated gonorrhea
Vincent's infection
Clostridium species

§  Adjunctive therapy in acute intestinal amebiasis and severe acne



§  It is contraindicated in patients with known hypersensitivity to tetracyclines.

§  May cause permanent discoloration of the teeth (yellow-gray-brown) if used during tooth development (last 1/2 of pregnancy, infancy, and childhood to 8 yrs of age); do not use in this age group, except for anthrax.



Precaution & warnings:

§  Clostridium difficile-associated diarrhea (CDAD) reported; discontinue if CDAD is suspected or confirmed.

§  May decrease fibula growth rate in prematures.

§  May cause an increase in BUN.

§  Photosensitivity, manifested by an exaggerated sunburn reaction, reported; discontinue at the 1st evidence of skin erythema.

§  May result in bacterial resistance if used in the absence of proven or suspected bacterial infection, or a prophylactic indication; take appropriate measures if superinfection develops.

§  Associated with intracranial HTN (pseudotumor cerebri); increased risk in women of childbearing age who are overweight or have a history of intracranial HTN. If visual disturbance occurs, prompt ophthalmologic evaluation is warranted. Intracranial pressure can remain elevated for weeks after drug cessation; monitor patients until they stabilize.

§  Incision and drainage or other surgical procedures should be performed in conjunction with antibacterial therapy when indicated.

§  False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.


 Pregnancy & Breastfeeding:


Category D, not for use in nursing.


Dosage and administration:


Adults >8 Years (>45 kg):


Initial: 100mg q12h or 50mg q6h on 1st day
Maint: 100mg qd or 50mg q12h
More Severe Infections (eg, Chronic UTIs): 100mg q12h


Side effects:


Diarrhea, hepatotoxicity, maculopapular/erythematous rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, anorexia, nausea, vomiting, urticaria, serum sickness, pericarditis, hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia.




Drug interaction:

§  Avoid concomitant use with isotretinoin; may increase risk of intracranial HTN.

§  Depresses plasma prothrombin activity; may require downward adjustment of anticoagulant dose.

§  May interfere with bactericidal action of PCN; avoid concurrent use.

§  Impaired absorption with antacids containing aluminum, Ca2+, or Mg2+, and iron-containing preparations.

§  Decreased T1/2 with barbiturates, carbamazepine, and phenytoin.

§  Fatal renal toxicity reported with methoxyflurane.


§  May render oral contraceptives less effective.




Store below 30°C.

Keep out of reach of children.




PDR 2015

Martindale 36

USP DI 2009

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